HA and HS Changes in Endothelial Inflammatory Activation
نویسندگان
چکیده
منابع مشابه
Pro-inflammatory activation of endothelial cells and its counter-regulation
In the setting of infection or wound healing, a tightly controlled pro-inflammatory and pro-thrombotic conversion of the endothelial phenotype is a beneficial biological response which helps to combat infection and renew organ integrity. However, prolonged endothelial activation, which has escaped control mechanisms of the host, may set off unfavorable sequelae, such as atherosclerosis and intr...
متن کاملMicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
Activation of inflammatory pathways in the endothelium contributes to vascular diseases, including sepsis and atherosclerosis. We demonstrate that miR-146a and miR-146b are induced in endothelial cells upon exposure to pro-inflammatory cytokines. Despite the rapid transcriptional induction of the miR-146a/b loci, which is in part mediated by EGR-3, miR-146a/b induction is delayed and sustained ...
متن کاملThe Changes in the Endothelial Function and Haemostatic and Inflammatory Parameters in Subclinical and Overt Hyperthyroidism
Introduction. The aim of the present study was to compare the levels of circulating markers of endothelial function and low-grade inflammation in patients with subclinical and overt hyperthyroidism (OH) due to Graves disease (GD) and toxic nodular goiter (TNG). Material and Methods. The group studied consisted of 42 patients with GD, 75 patients with TNG, and 39 healthy controls. Results. Circu...
متن کاملHyperglycemia- Induced NF-κB Activation Increases microRNA-146a Expression in Human Umbilical Vein Endothelial Cells
Background & objectives: Nuclear Factor kappa B (NF-κB), a master switch transcription factor, plays a critical role in the progression and development of hyperglycemia-induced microangiopathy. Hyperglycemia activates NF-κB, and subsequently increases pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β leading to development of inflammation. Some new studies have revealed the involvement o...
متن کاملIn vitro endothelial cell activation and inflammatory responses in end-stage heart failure.
BACKGROUND vascular endothelial cell activation and dysfunction are observed in patients with severe heart failure and may contribute to systemic manifestations of this syndrome. It remains unknown whether inflammatory activation of these cells occurs in these patients because of increased circulating proinflammatory mediators. AIM to determine whether the serum from patients with heart failu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomolecules
سال: 2021
ISSN: 2218-273X
DOI: 10.3390/biom11060809